In an ongoing randomized trial, Dr. Daniel H.S. Silverman, Dr. Natalie L. Rasgon, and their colleagues are examining the effects of both endogenous and exogenous estrogen exposure on regional cerebral metabolism in women who were on hormone therapy (HT) at the time of recruitment and had an increased risk of Alzheimer's disease. These women either stopped or continued HT and then underwent fluorine-18 FDG-PET imaging at baseline and at 2 years. Dr. Silverman, head of the neuronuclear imaging section of the Ahmanson Biological Imaging Division at the University of California, Los Angeles, presented data at the San Antonio Breast Cancer Symposium on the first 25 women to complete the protocol.