TPA Dose Cap May Not Suffice in Heavier Patients: Max 90 mg may not be enough for some.

NEW ORLEANS — Capping the weight-based dose of intravenous tissue plasminogen activator at 90 mg in patients who experience acute ischemic stroke, as per current guidelines, may compromise outcomes in those weighing more than 100 kg, Dr. Min Lou reported at International Stroke Conference 2008.