The Centers for Disease Control and Prevention has updated its exhaustive 1994 guidelines for preventing Mycobacterium tuberculosis in health care settings to respond to “shifts in the epidemiology of TB, advances in scientific understanding, and changes in health care practice that have occurred in the United States during the previous decade,” wrote the authors, led by Paul A. Jensen, Ph.D., in the division of tuberculosis elimination at the CDC's National Center for HIV, STD, and TB Prevention (MMWR 2005;54[RR-17]:1–121).